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Intravenous immunoglobulin in the therapy of systemic vasculitis

Transfusion Science, ISSN: 0955-3886, Vol: 13, Issue: 3, Page: 317-324
1992
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Article Description

The current therapy of the systemic vasculitides with corticosteroid and cytotoxic drugs is successful in controlling disease in the majority of patients but is limited by adverse effects; drugs must also be continued in the long-term as relapse frequently follows their withdrawal. Autoantibodies to neutrophil cytoplasmic antigens (ANCA) are associated with systemic vasculitis and have been implicated in its pathogenesis. Interest in the use of pooled immunoglobulin (IVIg) in the therapy of vasculitis has followed the detection of antiidiotype antibodies to ANCA in IVIg and the success of IVIg in the treatment of Kawasaki disease, an ANCA positive childhood vasculitis.

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