Differential expression of the 67-kD laminin receptor and 31-kD human laminin-binding protein in human ovarian carcinomas
European Journal of Cancer, ISSN: 0959-8049, Vol: 30, Issue: 8, Page: 1096-1099
1994
- 114Citations
- 7Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations114
- Citation Indexes114
- 114
- CrossRef73
- Captures7
- Readers7
Article Description
The expression of the 67-kD laminin receptor (67LR) and the 31-kD human laminin-binding protein (HLBP31), two proteins involved in cancer cell laminin interaction, was evaluated on 30 ovarian cancer specimens. Expression of the 67LR was increased (up to 2.5-fold, in 87% of the patients), while HLBP31 expression was downregulated in cancer cells compared with the normal tissue, as detected by northern blotting and immunohistochemistry. The immunohistochemical study demonstrated that the 67LR was significantly overexpressed ( P < 0.05) in the group of patients whose cytoreductive surgery was suboptimal, and those with poor clinical outcome. No correlation was observed between HLBP31 expression and clinicopathological features. Increased expression of the 67LR appears to correlate with the invasive phenotype of ovarian cancer cells and suggests a role of the latter in ovarian cancer invasion.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/0959804994904642; http://dx.doi.org/10.1016/0959-8049(94)90464-2; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0028049929&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/7654437; https://linkinghub.elsevier.com/retrieve/pii/0959804994904642; http://dx.doi.org/10.1016/0959-8049%2894%2990464-2; https://dx.doi.org/10.1016/0959-8049%2894%2990464-2
Elsevier BV
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