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Transdermal Drug Delivery and Percutaneous Absorption

Heat Transfer and Fluid Flow in Biological Processes, Page: 273-304
2015
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Book Chapter Description

Transdermal drug delivery is the systemic or topical release of drugs by percutaneous permeation. It offers several advantages, such as limitation of hepatic first pass metabolism and enhancement of therapeutic efficacy, providing an attractive alternative to oral delivery and hypodermic injections. For the optimization of the effective transdermal release, it is important to understand the mechanism of drug permeation from the vehicle (any delivery device such as a transdermal patch or medicated plaster) across the biological tissues composing the skin. This requires using appropriate mathematical models such as compartment and complex models or slow binding/partitioning kinetics which are reviewed in this chapter. This chapter also reviews novel and efficient solution techniques based on the Laplace transform method, on the finite difference method, the finite element method, and the finite volume method.

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