PlumX Metrics
Embed PlumX Metrics

Multitarget-Directed Antioxidants as Therapeutic Agents

Design of Hybrid Molecules for Drug Development, Page: 5-46
2017
  • 8
    Citations
  • 0
    Usage
  • 25
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Book Chapter Description

Melatonin is a neurohormone produced in the pineal gland that regulates circadian rhythmicity, with maximal secretion at night. The natural decline of melatonin levels with age strongly contributes to the development of neurodegenerative disorders. Currently, melatonin is recognized as a powerful antioxidant compound, able to efficiently scavenge different types of ROS in vitro, in body fluids, and in cells. Thus it is not surprising that a number of modified melatonin derivatives have been designed, synthesized, and biologically assessed, resulting in new multitarget-directed ligands (MTDL). In this chapter we identify the melatonin hybrids resulting from the juxtaposition of tacrine, berberine, tamoxifen, curcumin, N, N- dibenzyl( N -methyl)amine, cinnamic acid, sulforaphane, pinoline, or meptazinol with melatonin. We discuss their pharmacological properties and highlighting in particular their antioxidant capacity as potential therapeutic agents for diverse pathologies. Other antioxidant agents such as ferulic acid as a source for new MTDL are also discussed.

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know