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Marginal Vitamin C Deficiency, Lipid Metabolism, and Atherogenesis

Advances in Lipid Research, ISSN: 0065-2849, Vol: 16, Page: 167-220
1978
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Book Chapter Description

This chapter discusses marginal vitamin C deficiency, lipid metabolism, and atherogenes. Vitamin C holds a special position among the vitamins, because most vertebrates synthesize it in the glucuronic acid pathway of glucose metabolism and are, therefore, not dependent on a supply from external sources. Cholesterol atherosclerosis in guinea pigs, as distinct from rabbits, develops in the presence of relatively low plasma-cholesterol levels reminiscent of human hypercholesterolemia. There is also a parallel with the pathogenesis of human atherosclerosis in the slow development of atherosclerotic lesions in guinea pigs. The lipoprotein metabolism of guinea pigs is very different from that of man because normal guinea pig plasma contains no detectable high-density lipoproteins and no lipoproteins with alpha mobility. Serum and tissue cholesterol concentrations are the outcome of a great number of processes mutually bound by feedback mechanisms, such as cholesterol distribution between blood and tissues, endogenous cholesterol synthesis, the absorption of exogenous cholesterol, cholesterol excretion, and the transformation of cholesterol to bile acids.

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