Divalent Metal Cations in DNA–Phospholipid Binding
Advances in Planar Lipid Bilayers and Liposomes, ISSN: 1554-4516, Vol: 20, Page: 111-135
2014
- 5Citations
- 12Captures
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Book Chapter Description
Divalent metal cations are actively involved in cell's physiology and biochemistry. In addition to many others roles in cells, they mediate interaction between DNA and phospholipid bilayer. This chapter discusses the ability of divalent metal cations and phospholipid bilayers to condense DNA and to protect it against thermal denaturation. The microstructure of formed aggregates was studied using small-angle X-ray diffraction. Structural polymorphism induced by cations, ionic strength, and temperature generates a large variety of liquid-crystalline phases: condensed lamellar phases with or without DNA regular packing, coexistence of two lamellar phases, and also volume phases separation, which were identified in DNA-phopsholipid-cations mixtures. In addition to the alkaline earth metal cations, calcium and magnesium, transition metals (cobalt, manganese, nickel), and zinc are discussed as well.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/B9780124186989000046; http://dx.doi.org/10.1016/b978-0-12-418698-9.00004-6; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84904466314&origin=inward; http://linkinghub.elsevier.com/retrieve/pii/B9780124186989000046; http://api.elsevier.com/content/article/PII:B9780124186989000046?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:B9780124186989000046?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/B9780124186989000046; https://dx.doi.org/10.1016/b978-0-12-418698-9.00004-6
Elsevier BV
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