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Epiblast Development

Encyclopedia of Reproduction, Page: 341-346
2018
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Book Chapter Description

The inner cell mass in mammalian embryos differentiates before implantation into pluripotent epiblast and primitive endoderm. NANOG and GATA6 are key molecules in the segregation of epiblast and primitive endoderm respectively. In mice, anterior–posterior axis formation is driven by the visceral endoderm, originating from the primitive endoderm. The formation of the definitive germ layers starts at the posterior part of the epiblast at a structure called primitive streak. Epiblast cells migrate through the primitive streak to form definitive endoderm and mesoderm. Although the cells maintain a high level of developmental flexibility, the position in the epiblast determines their fate.

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