Vitamin D Nutrient-Gene Interactions and Healthful Aging
Molecular Basis of Nutrition and Aging, Page: 449-471
2016
- 2Citations
- 16Captures
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Book Chapter Description
1,25-Dihydroxyvitamin D 3 (1,25D) is the endocrine metabolite of vitamin D that signals through binding to the vitamin D receptor (VDR). The ligand–receptor complex transcriptionally regulates genes that encode factors promoting intestinal calcium and phosphate absorption plus bone remodeling, maintaining a skeleton with reduced risk of age-related osteoporotic fractures. 1,25D/VDR signaling further exerts feedback control of mineral ions via regulation of FGF23, klotho, and CYP24A1 to prevent age-related, ectopic calcification, and associated pathologies. Vitamin D also elicits xenobiotic detoxification, oxidative stress reduction, antimicrobial defense, immunoregulation, anti-inflammatory/anticancer actions, and cardiovascular benefits. 1,25D exerts neuroprotective actions against excitotoxicity, and induces serotonin mood elevator to support cognitive function and prosocial behavior. Nutrient, low-affinity VDR ligands including curcumin, polyunsaturated fatty acids, and delphinidin/anthocyanidins initiate VDR signaling, whereas longevity agents such as resveratrol and SIRT1 potentiate VDR signaling. Therefore, liganded VDR modulates the expression of a network of genes that facilitates health span by delaying the chronic diseases of aging.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/B9780128018163000339; http://dx.doi.org/10.1016/b978-0-12-801816-3.00033-9; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84978347263&origin=inward; http://linkinghub.elsevier.com/retrieve/pii/B9780128018163000339; http://api.elsevier.com/content/article/PII:B9780128018163000339?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:B9780128018163000339?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/B9780128018163000339; https://dx.doi.org/10.1016/b978-0-12-801816-3.00033-9
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