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Targeting Angiogenesis in Neuroblastoma

Neuroblastoma, Page: 79-93
2019
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Book Chapter Description

Antiangiogenic strategies are currently in use for the treatment of cancer, and the inhibition of angiogenesis could represent a powerful adjunct to traditional therapy of malignant tumors. Over the last 20 years, several reports have been published concerning the relationship between tumor progression and angiogenesis in neuroblastoma (NB) in experimental models in vitro and in vivo. Moreover, a high vascular index in NB correlates with poor prognosis, suggesting a dependence of aggressive tumor growth on active angiogenesis. Here, I present an overview of the literature concerning the antiangiogenesis approach in the treatment of NB.

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