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Saffron’s role in metabolic disorders

Saffron, Page: 471-483
2020
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Book Chapter Description

Metabolic disorders are among the most common causes of terminal conditions, such as cardiovascular disease. Pharmacological studies have confirmed the effectiveness of certain medicinal plants in managing metabolic disorders including obesity, metabolic syndrome, and diabetes. In this chapter, the effects of saffron ( Crocus sativus L.) and its derivatives on obesity and diabetes are summarized based on evaluations from multiple experimental and clinical studies. In obesity, saffron derivatives may directly or indirectly inhibit pathophysiology by decreasing food intake, weight gain, inflammatory processes, oxidative stress, and reversing alterations in adipocytokines levels. In diabetes, saffron derivatives have antihyperglycemic and hypolipidemic properties that are able to prevent or treat complications associated with diabetes such as nephropathy, neuropathy, retinopathy, liver damage, and cardiovascular disorders. The mechanisms involved in the antihyperglycemic property of saffron are discussed in this chapter, as are its protective effects against diabetic complications.

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