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CSF and disease

Cerebrospinal Fluid and Subarachnoid Space, Page: 31-46
2023
  • 1
    Citations
  • 0
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  • 13
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Book Chapter Description

Cerebrospinal fluid (CSF) can be useful for detecting metastases in the central nervous system, especially leptomeningeal metastases, which can occur with or without brain metastases. Leptomeningeal metastasis can result from various noncentral nervous system solid tumors and hematological malignancies. In this chapter we review the etiology, epidemiology, pathogenesis, and clinical presentation of leptomeningeal metastases, and the use of CSF (cerebrospinal fluid) evaluation for detecting brain metastases. Diagnostic tools include imaging and CSF analysis and the liquid biopsy approach. Prompt diagnosis of leptomeningeal disease is challenging, though it is important for addressing associated symptoms effectively. Leptomeningeal metastases traditionally carry a poor prognosis, but some emerging therapies are promising.

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