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HP experimental methods: cells and animals

Advances in Magnetic Resonance Technology and Applications, ISSN: 2666-9099, Vol: 3, Page: 75-91
2021
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Book Chapter Description

This chapter describes the essential components of preclinical testing of hyperpolarized 13 C labeled substrates for the uninitiated. Its focus is on the unique aspects of executing a successful hyperpolarized study, starting from the dissolution stage to the delivery into the biological system. A detailed discussion of the range of model systems at various testing phases and its unique advantages and disadvantages are presented. After reading this chapter, the reader should have a basic knowledge of how hyperpolarized 13 C MRI probes are tested and used to investigate biomedical questions.

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