Zebrafish xenotransplantation: A versatile platform for cancer and stem cell translational research
Cellular and Molecular Approaches in Fish Biology, Page: 347-379
2022
- 1Citations
- 15Captures
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Book Chapter Description
The zebrafish has emerged as a robust animal model for preclinical anticancer drug screening and as an important tool for personalized medicine. Zebrafish produce large clutches of offspring, have been genetically manipulated to be optically transparent, and undergo rapid development resulting in functional organogenesis by 48 h postfertilization. These characteristics, along with the relatively cost-effective housing and husbandry, and live in vivo cell tracking, make the zebrafish an ideal platform for human cell xenotransplantation. The larval zebrafish has proven to be an effective model organism to study cancer progression and migration, as well as stem cell colony expansion. Candidate drug and moderate throughput unbiased drug screens are feasible. More recently, an adult zebrafish xenotransplantation model has demonstrated advantages in recapitulating the route and timing of drug administration in patients, providing a complementary preclinical platform. This chapter will discuss zebrafish xenotransplantation approaches used in cancer and stem cell research.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/B9780128222737000057; http://dx.doi.org/10.1016/b978-0-12-822273-7.00005-7; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85129096673&origin=inward; https://linkinghub.elsevier.com/retrieve/pii/B9780128222737000057; https://dx.doi.org/10.1016/b978-0-12-822273-7.00005-7
Elsevier BV
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