Polycaprolactone-based nanoparticles for advanced therapeutic applications

The recent advances in therapeutics are predicated upon the use of polymers to adequately domiciliated therapeutic compounds, engineered them to exert distinctive biological functions, and tailored them for a specific delivery. Poly-ε-caprolactone (PCL) is among the top polymers that are making a significant impact in the biomedical arena. The polymer stands out among its pairs due to its biodegradability, biocompatibility, excellent mechanical properties, high thermal stability, high encapsulation capacity, nontoxicity, low cost, and a slower rate of degradation. These features attracted the polymer’s extensive usage in drug delivery and various other biomedical applications over the last five decades. The emergence of nanomedicines during this period has escalated the impetus of PCL in advanced therapeutics. PCL-based nanoparticles have been designed with efficient control features on their superficial membrane and particular size dimension to adjust solubility, enable infiltration, enhance elasticity, and maneuver the release pattern of remedies for its release at the designated target site, and at a desired time and amount. This chapter aimed to provide the contributions of PCL-based nanoparticles in advanced therapeutics.