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6-Hydroxydopamine (6-OHDA) rodent model of Parkinson’s disease: Investigating neural control of cardiorespiratory function

Handbook of Animal Models in Neurological Disorders, Page: 493-506
2023
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Book Chapter Description

The neurotoxin 6-hydroxydopamine (6-OHDA) continues to constitute a valuable tool in modeling Parkinson’s disease (PD) in rodents. The classical method of intracerebral infusion of 6-OHDA involving massive destruction of nigrostriatal dopaminergic neurons is mainly used to investigate motor and nonmotor deficits associated with PD. Among nonmotor functions investigated in the 6-OHDA PD model, dysfunctions in neural control of cardiorespiratory function, as evidenced by baroreflex impairment and reductions in breathing activity and respiratory chemoreception, have been successfully illustrated. Cardiorespiratory dysfunction is correlated with brainstem neurodegeneration in PD. Nevertheless, the mechanisms involved in the neurodegeneration of neurons that control those functions in the medulla related to nigrostriatal disarrangement still require further investigation. Here, we discussed the impairment in cardiorespiratory function affected by a central injection of 6-OHDA as a model of PD.

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