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Biophysical Evaluation of Skin Reactivity in Atopic Patients

Asthma and Allergic Diseases, Page: 271-279
1998
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Book Chapter Description

Clinical experience suggests that contact dermatitis of the hands induced by exogenous factors is very common in subjects with atopic dermatitis (AD). About one-quarter of patients who have been affected by childhood atopic dermatitis suffer from recurrences in adult life, often localized to the hands, which are more frequently and intensively exposed to irritants. Moreover, the prevalence of hand eczema in persons with a history of atopic dermatitis is two to ten times higher than in non-atopics. In particular, occupational skin problems concerning risk occupations, i.e. involving daily exposure to chemicals, water, soil or wear (hairdressers, cleaners, automobile mechanics, assistant nurses, etc.), are common in atopic subjects. An atopic constitution seems not only to increase the risk of developing an irritant contact dermatitis of the hands, but also to influence the course of the dermatitis. in spite of attempts to standardize clinical judgement, there are wide variations in both assessment schemes and the interpretation of the use of clinical assessment techniques, making interobserver variations unavoidable. Therefore, although clinical parameters, especially those concerning the extension of the dermatitis, are irreplaceable, the monitoring of both overall skin conditions and particular skin areas by means of non-invasive bioengineering methods represents a fundamental support in clinical and experimental studies.

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