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Functional MRI in Parkinson's Disease Cognitive Impairment

International Review of Neurobiology, ISSN: 0074-7742, Vol: 144, Page: 29-58
2019
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Functional MRI in Parkinson's Disease Cognitive Impairment.

Int Rev Neurobiol. 2019;144:29-58. Epub 2018 Oct 17 Authors: Baggio HC, Junqué C PubMed: 30638456 Submit Comment

Article Description

Functional magnetic resonance imaging (fMRI) has been used to study the neural bases of cognitive deficits in Parkinson's disease for several years. Traditionally, task-based fMRI has been applied to study specific cognitive functions, providing information on disease-related alterations and regarding the physiological bases of normal cognition, the dopaminergic system, and the frontostriatal circuits. More recently, functional connectivity techniques using resting-state fMRI data have been developed. Unconstrained by specific cognitive tasks, these techniques allow assessing whole-brain patterns of connectivity believed to be useful proxies for the underlying functional architecture of the brain. These methods have shown that different types of Parkinson's disease-related cognitive deficits are associated with patterns of altered connectivity within and between resting-state intrinsic connectivity networks. Although methodological standardization and the vulnerability of fMRI techniques to artifacts mandate further technical refinement, early studies provide encouraging results regarding the potential of fMRI-derived parameters for the ultimate goal of individual-subject classification.

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