In vivo detection and quantification of chemicals that enhance protein stability
Analytical Biochemistry, ISSN: 0003-2697, Vol: 434, Issue: 1, Page: 181-186
2013
- 14Citations
- 47Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations14
- Citation Indexes14
- 14
- CrossRef11
- Captures47
- Readers47
- 47
Article Description
We have devised protein-folding sensors that link protein stability to TEM-1 β–lactamase activity. The addition of osmolytes and other compounds with chemical chaperone activity to the growth medium of bacteria containing these sensors increases β–lactamase activity up to 207-fold in a dose-dependent manner. This enables the rapid detection and sensitive quantification of compounds that enhance in vivo protein stability.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0003269712006021; http://dx.doi.org/10.1016/j.ab.2012.11.022; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84872129645&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/23219982; https://linkinghub.elsevier.com/retrieve/pii/S0003269712006021
Elsevier BV
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