Sonochemically prepared BSA microspheres containing Gemcitabine, and their potential application in renal cancer therapeutics
Acta Biomaterialia, ISSN: 1742-7061, Vol: 5, Issue: 8, Page: 3031-3037
2009
- 44Citations
- 42Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations44
- Citation Indexes44
- 44
- CrossRef34
- Captures42
- Readers42
- 42
Article Description
This report demonstrates the formation and characterization of sonochemically prepared bovine serum albumin (BSA)–Gemzar (Gemcitabine) microspheres and shows their increased anticancer activity compared to pristine Gemzar. The amount of loaded Gemzar was determined by light absorption measurements. The BSA–Gemzar composite was analyzed and characterized by optical microscopy and scanning electron microscopy. The release kinetics of Gemzar from the proteinaceous microspheres was tested. The BSA–Gemzar composite was examined for its anticancer activity (in vitro) in renal cancer cells (RCC, 786-O cells) using [ 3 H]thymidine incorporation assays. It was found that the influence of the Gemzar-loaded microspheres on the cancer cells was significantly greater than that of an equimolar concentration of pristine Gemzar.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1742706109002116; http://dx.doi.org/10.1016/j.actbio.2009.05.003; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=70349202500&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/19442766; https://linkinghub.elsevier.com/retrieve/pii/S1742706109002116; https://dx.doi.org/10.1016/j.actbio.2009.05.003
Elsevier BV
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