Mucoadhesive and thermogelling systems for vaginal drug delivery
Advanced Drug Delivery Reviews, ISSN: 0169-409X, Vol: 92, Page: 39-52
2015
- 216Citations
- 367Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations216
- Citation Indexes216
- 216
- CrossRef55
- Captures367
- Readers367
- 367
Review Description
This review focuses on two formulation approaches, mucoadhesion and thermogelling, intended for prolonging residence time on vaginal mucosa of medical devices or drug delivery systems, thus improving their efficacy. The review, after a brief description of the vaginal environment and, in particular, of the vaginal secretions that strongly affect in vivo performance of vaginal formulations, deals with the above delivery systems. As for mucoadhesive systems, conventional formulations (gels, tablets, suppositories and emulsions) and novel drug delivery systems (micro-, nano-particles) intended for vaginal administration to achieve either local or systemic effect are reviewed. As for thermogelling systems, poly(ethylene oxide–propylene oxide–ethylene oxide) copolymer-based and chitosan-based formulations are discussed as thermogelling systems. The methods employed for functional characterization of both mucoadhesive and thermogelling drug delivery systems are also briefly described.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0169409X15000125; http://dx.doi.org/10.1016/j.addr.2015.02.001; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84943456474&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/25683694; https://linkinghub.elsevier.com/retrieve/pii/S0169409X15000125
Elsevier BV
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