Persistent hyperlactatemia-high central venous-arterial carbon dioxide to arterial-venous oxygen content ratio is associated with poor outcomes in early resuscitation of septic shock
The American Journal of Emergency Medicine, ISSN: 0735-6757, Vol: 35, Issue: 8, Page: 1136-1141
2017
- 13Citations
- 54Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations13
- Citation Indexes13
- 13
- CrossRef8
- Captures54
- Readers54
- 54
Article Description
Several studies reported Pv-aCO 2 /Ca-vO 2 ratio as a surrogate of VCO 2 /VO 2 to detect global tissue hypoxia. The present study aimed to evaluate the prognostic value of Pv-aCO 2 /Ca-vO 2 ratio combined with lactate levels during the early phases of resuscitation in septic shock. A retrospective study was conducted in 144 septic shock patients in a 30-bed mixed ICU. A Pv-aCO 2 /Ca-vO 2 ratio > 1.4 was considered abnormal. Patients were classified into four predefined groups according to lactate levels and Pv-aCO 2 /Ca-vO 2 ratio after the first 6 h of resuscitation. Sequential Organ Failure Assessment (SOFA) score at day 3 was assessed. A Kaplan-Meier curve showed the survival probabilities at day 28 using a log-rank test to evaluate the differences between groups. A receiver operating characteristics (ROC) curve evaluated the ability of lactate, Pv-aCO 2 /Ca-vO 2 ratio and Pv-aCO 2 /Ca-vO 2 ratio combined with lactate to predict mortality at day 28. Combination of hyperlactatemia and high Pv-aCO 2 /Ca-vO 2 ratio was associated with poor SOFA scores and low survival rates at day 28 ( P < 0.001). The Cox multivariate survival analysis demonstrated that Pv-aCO 2 /Ca-vO 2 ratio and lactate at T6 were independent predictors of mortality at day 28. The area under the ROC curve of the Pv-aCO 2 /Ca-vO 2 ratio combined with lactate for predicting mortality at day 28 was highest and superior to that of lactate and Pv-aCO 2 /Ca-vO 2 ratios. Combination of Pv-aCO 2 /Ca-vO 2 ratio and lactate at early stages of resuscitation of septic shock can better predict the prognosis of patients. The Pv-aCO 2 /Ca-vO 2 ratio may become a useful parameter supplementary to lactate in the resuscitation of septic shock.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0735675717301900; http://dx.doi.org/10.1016/j.ajem.2017.03.027; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85016000172&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/28341187; https://linkinghub.elsevier.com/retrieve/pii/S0735675717301900; https://dx.doi.org/10.1016/j.ajem.2017.03.027
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know