Cortical thickness and intrinsic activity changes in middle-aged men with alcohol use disorder
Alcohol, ISSN: 0741-8329, Vol: 106, Page: 15-21
2023
- 8Citations
- 17Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations8
- Citation Indexes8
- Captures17
- Readers17
- 17
Article Description
Previous studies reported the alterations of brain structure or function in people with alcohol use disorder (AUD). However, a multi-modal approach combining structural and functional studies is essential to understanding the neural mechanisms of AUD. Hence, we examined regional differences in cortical thickness (CT) and amplitude of low-frequency fluctuation (ALFF) in patients with AUD. Thirty male patients with AUD and thirty age- and education-matched healthy male controls were recruited. High-resolution anatomical and resting-state functional MRI (rs-fMRI) data were collected, and the CT and ALFF were computed. Behaviorally, males with AUD showed a cognitive decline in multiple domains. Structurally, they presented prominent reductions in CT in the bilateral temporal, insular, precentral, and dorsolateral prefrontal gyri ( p < 0.05, voxel-wise family-wise error [FWE]). Functionally, a significant decrease in ALFF in the bilateral temporal, dorsolateral prefrontal, insular, putamen, cerebellum, right precuneus, mid-cingulate, and precentral gyri were observed ( p < 0.05, FWE). Our findings demonstrate the dual alterations of alcohol-related brain structure and function in male patients with AUD. These results may be useful in understanding the neural mechanisms in AUD.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0741832922001008; http://dx.doi.org/10.1016/j.alcohol.2022.10.001; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85146711293&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/36272658; https://linkinghub.elsevier.com/retrieve/pii/S0741832922001008; https://dx.doi.org/10.1016/j.alcohol.2022.10.001
Elsevier BV
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