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Inosine reduces microcirculatory disturbance and inflammatory organ damage in experimental acute pancreatitis in rats

The American Journal of Surgery, ISSN: 0002-9610, Vol: 191, Issue: 4, Page: 510-514
2006
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Article Description

Despite improvement in the management of severe necrotizting pancreatitis, mortality remains high. Today, no specific treatment exists. Inflammatory cascades and microcirculatory disturbances play a key role in the pathogenesis of acute pancreatitis. The aim of the present study was to evaluate the effects of inosine, an immunomodulatory substance, on the severity of experimental necrotizing pancreatitis.

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