Fibrinolysis resistance after liver transplant as a predictor of early infection
The American Journal of Surgery, ISSN: 0002-9610, Vol: 224, Issue: 6, Page: 1455-1459
2022
- 2Citations
- 7Captures
- 2Mentions
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Metrics Details
- Citations2
- Citation Indexes2
- Captures7
- Readers7
- Mentions2
- News Mentions2
- News2
Most Recent News
Investigators at University of Colorado Anschutz Medical Campus Report Findings in Liver Transpls (Fibrinolysis Resistance After Liver Transplant As a Predictor of Early Infection)
2023 FEB 07 (NewsRx) -- By a News Reporter-Staff News Editor at Disease Prevention Daily -- Investigators publish new report on Transplant Medicine - Liver
Article Description
Infection is a leading cause of morbidity in liver transplant (LT). Considering that the fibrinolytic system is altered in sepsis, we investigated the relationship between fibrinolysis resistance (FR) and post-transplant infection. Fibrinolysis was quantified using thrombelastography (TEG) with the addition of tPA to quantify FR. FR was defined as LY30 = 0% and stratified as transient if present on POD1 or POD5 (tFR), persistent (pFR) if present on both, or no FR (nFR) if absent. 180 LT recipients were prospectively enrolled. 52 (29%) recipients developed infection. 72 had tFR; 37 had pFR; and 71 had nFR. Recipients with pFR had significantly greater incidence of infections (51% vs. 26% tFR vs. 20% nFR, p = 0.002). pFR was independently associated with increased odds of post-transplant infection (adjusted OR 3.39, p = 0.009). Persistent fibrinolysis resistance is associated with increased risk of post-transplant infection.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S000296102200558X; http://dx.doi.org/10.1016/j.amjsurg.2022.09.011; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85138803454&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/36153270; https://linkinghub.elsevier.com/retrieve/pii/S000296102200558X; https://dx.doi.org/10.1016/j.amjsurg.2022.09.011
Elsevier BV
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