StpC-based gene therapy targeting latent reservoirs of HIV-1
Antiviral Research, ISSN: 0166-3542, Vol: 72, Issue: 3, Page: 233-241
2006
- 7Citations
- 21Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations7
- Citation Indexes7
- CrossRef6
- Captures21
- Readers21
- 21
Article Description
The ability of HIV-1 to form latent reservoirs presents a major obstacle to eradication. One approach to elimination of the latent reservoir is induction therapy, whereby cells harboring latent virus are activated and therefore initiate virus replication. We have constructed a lentiviral vector encoding Herpesvirus saimiri subgroup C saimiri transformation-associated protein (StpC), which has been shown to modulate HIV-1 replication, under the control of a cytomegalovirus promoter in order to determine the ability of StpC to upregulate latent HIV-1. We have included a suicide gene, herpes simplex virus thymidine kinase (TK), under the control of the HIV-1 long terminal repeat (LTR) promoter. We hypothesized that upon StpC expression in latently infected cells induction of virus replication and subsequent production of viral transactivators of the LTR will activate expression of the tk gene, sensitizing the cells to the nucleoside analogue ganciclovir (GCV). Transduction of the latently infected cell line J1.1 resulted in increased virus replication. In the presence of GCV transduced cells exhibited decreased HIV-1 replication, inhibition of cell proliferation, and increased apoptosis. This prototype vector serves as a proof of concept of the utility of gene-based induction agents and suicide genes as a new method for targeting reservoirs of latent HIV-1.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0166354206001999; http://dx.doi.org/10.1016/j.antiviral.2006.06.010; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33750721630&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/16891001; https://linkinghub.elsevier.com/retrieve/pii/S0166354206001999; https://dx.doi.org/10.1016/j.antiviral.2006.06.010
Elsevier BV
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