Actively separated microneedle patch for sustained-release of growth hormone to treat growth hormone deficiency
Acta Pharmaceutica Sinica B, ISSN: 2211-3835, Vol: 13, Issue: 1, Page: 344-358
2023
- 33Citations
- 32Captures
- 2Mentions
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Metrics Details
- Citations33
- Citation Indexes33
- 33
- CrossRef4
- Captures32
- Readers32
- 32
- Mentions2
- News Mentions2
- 2
Most Recent News
Researchers' Work from Sun Yat-sen University Focuses on Growth Hormone Deficiency (Actively separated microneedle patch for sustained-release of growth hormone to treat growth hormone deficiency)
2023 FEB 17 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Daily -- New study results on growth hormone deficiency have
Article Description
Growth hormone deficiency (GHD) has become a serious healthcare burden, and presents a huge impact on the physical and mental health of patients. Here, we developed an actively separated microneedle patch (PAA/NaHCO 3 -Silk MN) based on silk protein for sustained release of recombinant human growth hormone (rhGH). Silk protein, as a friendly carrier material for proteins, could be constructed in mild full-water conditions and ensure the activity of rhGH. After manually pressing PAA/NaHCO 3 -Silk MN patch to skin for 1 min, active separation is achieved by absorbing the interstitial fluid (ISF) to trigger HCO 3 ‒ in the active backing layer to produce carbon dioxide gas (CO 2 ). In rats, the MN patch could maintain the sustained release of rhGH for more than 7 days, and produce similar effects as daily subcutaneous (S.C.) injections of rhGH in promoting height and weight with well tolerated. Moreover, the PAA/NaHCO 3 -Silk MN patch with the potential of painless self-administration, does not require cold chain transportation and storage possess great economic benefits. Overall, the PAA/NaHCO 3 -Silk MN patch can significantly improve patient compliance and increase the availability of drugs, meet current unmet clinical needs, improve clinical treatment effects of GHD patients.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S2211383522002039; http://dx.doi.org/10.1016/j.apsb.2022.04.015; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85130326001&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/36815043; https://linkinghub.elsevier.com/retrieve/pii/S2211383522002039; https://dx.doi.org/10.1016/j.apsb.2022.04.015; http://sciencechina.cn/gw.jsp?action=cited_outline.jsp&type=1&id=7423042&internal_id=7423042&from=elsevier
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