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Hypertension and angiogenesis in the aging kidney: A review

Archives of Gerontology and Geriatrics, ISSN: 0167-4943, Vol: 52, Issue: 3, Page: e93-e102
2011
  • 11
    Citations
  • 0
    Usage
  • 39
    Captures
  • 0
    Mentions
  • 75
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    11
  • Captures
    39
  • Social Media
    75
    • Shares, Likes & Comments
      75
      • Facebook
        75

Review Description

With advanced aging, main components of the kidney are altered, including blood vessels, glomeruli and tubulointerstitium. Disruption in these 3 elements is interconnected and associated with several modifications, such as loss of kidney mass and systemic, metabolic and immunologic diseases. In this review we focus on renal blood vessels, the key role of hypertension and angiogenesis in the elderly kidney, the hemodynamic and molecular mechanisms underlying this aging process and the main factors involved. So far, the present data suggests a strong association between renal disease and hypertension and the impairment of regulatory mechanisms, such as angiogenesis in the aging kidney. The endothelium is a key player in vascular control and appears to be also disrupted in many compensatory functions (i.e., vasodilation). Perspectives for the management of the dysfunctional aging kidney are also addressed.

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