Healthful aging mediated by inhibition of oxidative stress
Ageing Research Reviews, ISSN: 1568-1637, Vol: 64, Page: 101194
2020
- 156Citations
- 167Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations156
- Citation Indexes156
- 156
- CrossRef52
- Captures167
- Readers167
- 167
Review Description
The progressive increase in lifespan over the past century carries with it some adversity related to the accompanying burden of debilitating diseases prevalent in the older population. This review focuses on oxidative stress as a major mechanism limiting longevity in general, and healthful aging, in particular. Accordingly, the first goal of this review is to discuss the role of oxidative stress in limiting longevity, and compare healthful aging and its mechanisms in different longevity models. Secondly, we discuss common signaling pathways involved in protection against oxidative stress in aging and in the associated diseases of aging, e.g., neurological, cardiovascular and metabolic diseases, and cancer. Much of the literature has focused on murine models of longevity, which will be discussed first, followed by a comparison with human models of longevity and their relationship to oxidative stress protection. Finally, we discuss the extent to which the different longevity models exhibit the healthful aging features through physiological protective mechanisms related to exercise tolerance and increased β-adrenergic signaling and also protection against diabetes and other metabolic diseases, obesity, cancer, neurological diseases, aging-induced cardiomyopathy, cardiac stress and osteoporosis.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1568163720303299; http://dx.doi.org/10.1016/j.arr.2020.101194; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85094560413&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/33091597; https://linkinghub.elsevier.com/retrieve/pii/S1568163720303299; https://dx.doi.org/10.1016/j.arr.2020.101194
Elsevier BV
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