A single nucleotide polymorphism of the apolipoprotein A–V gene −1131T > C modulates postprandial lipoprotein metabolism
Atherosclerosis, ISSN: 0021-9150, Vol: 189, Issue: 1, Page: 163-168
2006
- 30Citations
- 28Captures
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Article Description
The Apolipoprotein A–V (apoA–V) gene promoter polymorphism −1131T > C modulates triacylglycerol (TG) concentrations. We evaluate whether this polymorphism could be involved in the interindividual variability observed during postprandial lipemia. Fifty-one healthy apo E3E3 male volunteers [12 with −1131CC/CT genotype, and 39 with −1131TT genotype] underwent a Vitamin A fat-load test consisting of 1 g of fat/kg body weight and 60,000 IU of Vitamin A. Blood samples were taken at time 0 and every hour until the 6th and every 2 h and 30 min until the 11th. Cholesterol (Chol) and TG were determined in plasma and Chol, TG, ApoB-100, ApoB-48, and retinyl palmitate (RP) were determined in lipoprotein fractions. Data of postprandial lipemia revealed that subjects with the −1131CT/CC genotype had a higher postprandial response of total plasma TG ( p = 0.043), large triacylglycerol-rich lipoproteins-TG (TRL-TG) ( p = 0.002), large TRL-Chol ( p = 0.004), small TRL-Chol ( p = 0.004) and small TRL-RP ( p = 0.001) than subjects with the −1131TT genotype. The modifications observed in postprandial lipoprotein metabolism in subjects with the apoA–V −1131T > C polymorphism could be involved in the increased fasting plasma TG concentrations previously described in carriers of the C allele.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S002191500500780X; http://dx.doi.org/10.1016/j.atherosclerosis.2005.11.029; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33748956625&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/16386743; https://linkinghub.elsevier.com/retrieve/pii/S002191500500780X
Elsevier BV
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