PlumX Metrics
Embed PlumX Metrics

A single nucleotide polymorphism of the apolipoprotein A–V gene −1131T > C modulates postprandial lipoprotein metabolism

Atherosclerosis, ISSN: 0021-9150, Vol: 189, Issue: 1, Page: 163-168
2006
  • 30
    Citations
  • 0
    Usage
  • 28
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    30
    • Citation Indexes
      29
    • Patent Family Citations
      1
      • Patent Families
        1
  • Captures
    28

Article Description

The Apolipoprotein A–V (apoA–V) gene promoter polymorphism −1131T > C modulates triacylglycerol (TG) concentrations. We evaluate whether this polymorphism could be involved in the interindividual variability observed during postprandial lipemia. Fifty-one healthy apo E3E3 male volunteers [12 with −1131CC/CT genotype, and 39 with −1131TT genotype] underwent a Vitamin A fat-load test consisting of 1 g of fat/kg body weight and 60,000 IU of Vitamin A. Blood samples were taken at time 0 and every hour until the 6th and every 2 h and 30 min until the 11th. Cholesterol (Chol) and TG were determined in plasma and Chol, TG, ApoB-100, ApoB-48, and retinyl palmitate (RP) were determined in lipoprotein fractions. Data of postprandial lipemia revealed that subjects with the −1131CT/CC genotype had a higher postprandial response of total plasma TG ( p = 0.043), large triacylglycerol-rich lipoproteins-TG (TRL-TG) ( p = 0.002), large TRL-Chol ( p = 0.004), small TRL-Chol ( p = 0.004) and small TRL-RP ( p = 0.001) than subjects with the −1131TT genotype. The modifications observed in postprandial lipoprotein metabolism in subjects with the apoA–V −1131T > C polymorphism could be involved in the increased fasting plasma TG concentrations previously described in carriers of the C allele.

Bibliographic Details

Moreno, Rafael; Perez-Jimenez, Francisco; Marin, Carmen; Moreno, Juan Antonio; Gomez, Purificación; Bellido, Cecilia; Perez-Martinez, Pablo; Jimenez-Gomez, Yolanda; Fuentes, Francisco Jose; Lopez-Miranda, Jose

Elsevier BV

Medicine

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know