Sex differences of carotid intima-media thickness in healthy children and adolescents
Atherosclerosis, ISSN: 0021-9150, Vol: 206, Issue: 2, Page: 458-463
2009
- 83Citations
- 66Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations83
- Citation Indexes79
- 79
- CrossRef63
- Clinical Citations2
- PubMed Guidelines2
- Policy Citations2
- Policy Citation2
- Captures66
- Readers66
- 66
Article Description
In pediatric cardiovascular health prevention non-invasive diagnostics of subclinical atherosclerosis is essential for screenings and interventional purposes. Increased carotid artery intima-media thickness (IMT) has been reported in the presence of cardiovascular risk factors in childhood. However, little information exists regarding the age and sex distribution of IMT as stated in adults. This study investigates first, if IMT sonography is reliable and feasible; second, calculates sex- and age-specific percentiles; third, re-confirms IMT associations to cardiovascular risk parameters and analyses predictors for age-adjusted IMT. 267 healthy pupils (age 6–17 years) were examined prospectively. Standardized IMT sonography and offline analysis were performed. Anthropometric data, BMI, body composition, blood pressure were taken; Spearman's rank correlation coefficient and multiple stepwise linear regression analyses were calculated. Intra-observer variability: CV was 2.42% ( n = 132; MD = 0.012 mm; r = 0.849); inter-observer variability: CV was 1.71% ( n = 75; MD = 0.013 mm; r = 0.780). Age- and sex-specific IMT percentiles for age groups 8/9 to 14/15 years were calculated. IMT values were higher in boys than in girls at the same age. Systolic blood pressure and IMT were positively related in boys ( p < 0.001, r = 0.31) and girls ( p = 0.005, r = 0.24). Predictors for age-adjusted IMT: systolic blood pressure was shown to be a predictor ( r 2 = 0.10, β = 0.31, p < 0.001) in boys; weight emerged as a predictor ( r 2 = 0.19, β = 0.43, p < 0.001) in girls. The main study benefit is the provision of IMT percentiles for both sexes for the age groups 8/9 to 14/15 years. The results suggest that sex-specific prevention should be given further attention in a comprehensive and multi-risk parameters approach.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0021915009002214; http://dx.doi.org/10.1016/j.atherosclerosis.2009.03.016; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=70349416590&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/19389672; https://linkinghub.elsevier.com/retrieve/pii/S0021915009002214
Elsevier BV
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