PlumX Metrics
Embed PlumX Metrics

Review of pre-metastatic niches in lung metastasis: From cells to molecules, from mechanism to clinics

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, ISSN: 0304-419X, Vol: 1879, Issue: 2, Page: 189081
2024
  • 2
    Citations
  • 0
    Usage
  • 7
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Review Description

Distant metastasis is responsible for high mortality in most cancer cases and the lung is one of the most common target organs, severely affecting the quality of daily life and overall survival of cancer patients. With relevant research breakthroughs accumulating, scientists have developed a deeper understanding of lung metastasis (LM) from the rudimentary “seed and soil” theory to a more vivid concept of the pre-metastatic niche (PMN). Thus, the mechanisms of PMN formation become considerably complicated, involving various types of cells, chemokines, cytokines, and proteins, providing potential biomarkers for improved LM diagnosis and treatment techniques. Here we summarized the latest findings (in 3 years) of lung PMN and systematically collated it from basic research to clinical application, which clearly exhibited the influences of the primary tumor, stromal, and bone marrow-derived cells (BMDCs) and associated molecules in the formation of lung PMN.

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know