Microinjection of ritanserin into the dorsal hippocampal CA1 and dentate gyrus decrease nociceptive behavior in adult male rat
Behavioural Brain Research, ISSN: 0166-4328, Vol: 168, Issue: 2, Page: 221-225
2006
- 48Citations
- 17Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations48
- Citation Indexes48
- 48
- CrossRef44
- Captures17
- Readers17
- 17
Article Description
Prenatal 5HT depletion causes a significant decrease in the level of nociceptive sensitivity during the second phase of the formalin test behavioral response. These experiments were designed to test whether blocking 5HT 2A/2c receptors in the CA1 region of the hippocampus and dentate gyrus would decrease nociceptive behaviors induced by a peripheral noxious stimulus formalin as an animal model of unremitting human being. The 5HT 2A/2c receptor antagonist ritanserin (2, 4 and 8 μg/0.5 μl) was injected into the CA1 area and dentate gyrus of behaving rats 5 min before subcutaneous injection of formalin irritant. Nociceptive behaviors in both phases of the formalin test were significantly decreased by ritanserin (4 and 8 μg/0.5 μl) and ritanserin had no effect at 2 μg/0.5 μl. These results support the hypothesis that the hippocampal formation may modify the processing of incoming nociceptive information and that 5HT 2A/2c receptor-sensitive mechanisms in the hippocampus may play a role in nociception and/or the expression of related behaviors.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0166432805004912; http://dx.doi.org/10.1016/j.bbr.2005.11.011; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=32044454879&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/16377002; https://linkinghub.elsevier.com/retrieve/pii/S0166432805004912; https://dx.doi.org/10.1016/j.bbr.2005.11.011
Elsevier BV
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