Processing of ovine PrPARQC-EGFP chimeras containing Asn 138 and Cys 151 polymorphisms
Biochemical and Biophysical Research Communications, ISSN: 0006-291X, Vol: 336, Issue: 2, Page: 544-553
2005
- 3Citations
- 12Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations3
- Citation Indexes3
- CrossRef2
- Captures12
- Readers12
- 12
Article Description
Polymorphisms in the prion protein, PrP C, affect the susceptibility of sheep to scrapie. Three rare polymorphisms, M137T, S138N, and R151C, have been found in Icelandic sheep. Observations suggest that R151C may be associated with lower scrapie susceptibility, whereas S138N is neutral. The effects of the S138N and R151C polymorphisms on the cellular processing of PrP C were examined in a model system consisting of the expression of ovine PrP C -EGFP (green fluorescent protein) chimeras in the mouse neuroblastoma cell line N2a. Chimeras with the haplotypes A 136 R 154 Q 171 (ARQ), AN 138 RQ, and AC 151 RQ were compared. The chimeras did not differ regarding their translocation into the secretory system, glycosylation, and transport to the cell surface. However, the AC 151 RQ chimera differed from the other chimeras regarding disulfide bonding characteristics; furthermore, a slight difference was detected between AC 151 RQ and the other chimeras by limited proteolysis. The processing of the ARQ and AN 138 RQ chimeras was identical in the experiments performed consistent with observations that it is neutral.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0006291X05017973; http://dx.doi.org/10.1016/j.bbrc.2005.08.124; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=24644505350&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/16143302; https://linkinghub.elsevier.com/retrieve/pii/S0006291X05017973; https://dx.doi.org/10.1016/j.bbrc.2005.08.124
Elsevier BV
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