PlumX Metrics
Embed PlumX Metrics

Metalloantibiotic Mn(II)–bacitracin complex mimicking manganese superoxide dismutase

Biochemical and Biophysical Research Communications, ISSN: 0006-291X, Vol: 341, Issue: 4, Page: 925-930
2006
  • 39
    Citations
  • 0
    Usage
  • 32
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

Superoxide dismutase (SOD) activities of various metallobacitracin complexes were evaluated using the riboflavin-methionine-nitro blue tetrazolium assay. The radical scavenging activity of various metallobacitracin complexes was shown to be higher than those of the negative controls, e.g., free transition metal ions and metal-free bacitracin. The SOD activity of the complex was found to be in the order of Mn(II) > Cu(II) > Co(II) > Ni(II). Furthermore, the effect of bacitracin and their complexation to metals on various microorganisms was assessed by antibiotic susceptibility testing. Moreover, molecular modeling and quantum chemical calculation of the metallobacitracin complex was performed to evaluate the correlation of electrostatic charge of transition metal ions on the SOD activity.

Bibliographic Details

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know