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Parafibromin inhibits cancer cell growth and causes G1 phase arrest

Biochemical and Biophysical Research Communications, ISSN: 0006-291X, Vol: 350, Issue: 1, Page: 17-24
2006
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Article Description

The HRPT2 (hereditary hyperparathyroidism type 2) tumor suppressor gene encodes a ubiquitously expressed 531 amino acid protein termed parafibromin. Inactivation of parafibromin predisposes one to the development of HPT-JT syndrome. To date, the role of parafibromin in tumorigenesis is largely unknown. Here, we report that parafibromin is a nuclear protein that possesses anti-proliferative properties. We show that overexpression of parafibromin inhibits colony formation and cellular proliferation, and induces cell cycle arrest in the G1 phase. Moreover, HPT-JT syndrome-derived mutations in HRPT2 behave in a dominant-negative manner by abolishing the ability of parafibromin to suppress cell proliferation. These findings suggest that parafibromin has a critical role in cell growth, and mutations in HRPT2 can directly inhibit this role.

Bibliographic Details

Zhang, Chun; Kong, Dong; Tan, Min-Han; Pappas, Donald L; Wang, Peng-Fei; Chen, Jindong; Farber, Leslie; Zhang, Nian; Koo, Han-Mo; Weinreich, Michael; Williams, Bart O; Teh, Bin Tean

Elsevier BV

Biochemistry, Genetics and Molecular Biology

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