Rsf-1 is overexpressed in non-small cell lung cancers and regulates cyclinD1 expression and ERK activity
Biochemical and Biophysical Research Communications, ISSN: 0006-291X, Vol: 420, Issue: 1, Page: 6-10
2012
- 23Citations
- 8Captures
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Metrics Details
- Citations23
- Citation Indexes23
- 23
- CrossRef19
- Captures8
- Readers8
Article Description
Rsf-1 (HBXAP) was recently reported to be overexpressed in various cancers and associated with the malignant behavior of cancer cells. However, the expression of Rsf-1 in primary lung cancer and its biological roles in non-small cell lung cancer (NSCLC) have not been reported. The molecular mechanism of Rsf-1 in cancer aggressiveness remains ambiguous. In the present study, we analyzed the expression pattern of Rsf-1 in NSCLC tissues and found that Rsf-1 was overexpressed at both the mRNA and protein levels. There was a significant association between Rsf-1 overexpression and TNM stage ( p = 0.0220) and poor differentiation ( p = 0.0013). Furthermore, knockdown of Rsf-1 expression in H1299 and H460 cells with high endogenous Rsf-1 expression resulted in a decrease of colony formation ability and inhibition of cell cycle progression. Rsf-1 knockdown also induced apoptosis in these cell lines. Further analysis showed that Rsf-1 knockdown decreased cyclin D1 expression and phospho-ERK levels. In conclusion, Rsf-1 is overexpressed in NSCLC and contributes to malignant cell growth by cyclin D1 and ERK modulation, which makes Rsf-1 a candidate therapeutic target in lung cancer.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0006291X12003452; http://dx.doi.org/10.1016/j.bbrc.2012.02.095; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84862807031&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/22387541; https://linkinghub.elsevier.com/retrieve/pii/S0006291X12003452; https://dx.doi.org/10.1016/j.bbrc.2012.02.095
Elsevier BV
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