Shiga-like toxin-based high-efficiency and receptor-specific intracellular delivery system for a protein
Biochemical and Biophysical Research Communications, ISSN: 0006-291X, Vol: 464, Issue: 4, Page: 1282-1289
2015
- 8Citations
- 35Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations8
- Citation Indexes8
- CrossRef8
- Captures35
- Readers35
- 35
Article Description
The cell-specific cytosolic delivery of functional macromolecules with high efficiency is of great significance in molecular medicine and biotechnology. Herein, we present a Shiga-like toxin II-based high-efficiency and receptor-specific intracellular delivery system. We designed and constructed the Shiga-like toxin-based carrier (STC) to comprise the targeting and translocation domains, and used it for delivering a protein cargo. The STC was shown to deliver a protein cargo into the cytosol with high efficiency in a receptor-specific manner, exhibiting much higher efficiency than the most widely used cell-penetrating peptide. The general utility of the STC was demonstrated by modulating the targeting domain. The present delivery platform can be widely used for the intracellular delivery of diverse biomolecules in a receptor-specific and genetically encodable manner.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0006291X1530348X; http://dx.doi.org/10.1016/j.bbrc.2015.07.122; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84940460055&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/26220340; https://linkinghub.elsevier.com/retrieve/pii/S0006291X1530348X; https://dx.doi.org/10.1016/j.bbrc.2015.07.122
Elsevier BV
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