Safety assessment of two strains and anti-obese effects on mice fed a high-cholesterol diet
Biochemical and Biophysical Research Communications, ISSN: 0006-291X, Vol: 572, Page: 131-137
2021
- 3Citations
- 12Captures
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Article Description
Previous study documented that Lactobacillus paracasei S0940 and Streptococcus thermophilus ldbm1 have obvious cholesterol-lowering abilities in vitro. In this study, the safety of two strains were evaluated by nitroreductase test, hemolysis test and antibiotic sensitivity test and to evaluate the cholesterol-reducing abilities in vivo. The results indicated that two strains did not exhibit nitroreductase activities and were ɤ-hemolytic on blood agar plates. Further, both strains did not represent a health risk by antibiotic sensitivity test, and significantly reduced serum and liver cholesterol and triglyceride levels of high fat-fed mice. Compared with the high-fat model group, administration of the strains to mice fed a high-cholesterol diet increased fecal water content and fecal cholesterol and significantly improved the intestinal microbiota, which indicating that Lactobacillus paracasei S0940 and Streptococcus thermophilus ldbm1 have a positive effect on reducing cholesterol levels and may be used in functional food.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0006291X21011281; http://dx.doi.org/10.1016/j.bbrc.2021.07.089; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85111857276&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/34364292; https://linkinghub.elsevier.com/retrieve/pii/S0006291X21011281; https://dx.doi.org/10.1016/j.bbrc.2021.07.089
Elsevier BV
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