In vitro Blood–Brain barrier model based on recombinant spider silk protein nanomembranes for evaluation of transcytosis capability of biomolecules
Biochemical and Biophysical Research Communications, ISSN: 0006-291X, Vol: 669, Page: 77-84
2023
- 2Citations
- 10Captures
- 1Mentions
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Metrics Details
- Citations2
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- Captures10
- Readers10
- 10
- Mentions1
- News Mentions1
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Most Recent News
School of Engineering Sciences in Chemistry Reports Findings in Nanomembranes (In vitro Blood-Brain barrier model based on recombinant spider silk protein nanomembranes for evaluation of transcytosis capability of biomolecules)
2023 JUN 19 (NewsRx) -- By a News Reporter-Staff News Editor at Nanotech Daily -- New research on Nanotechnology - Nanomembranes is the subject of
Article Description
The blood–brain barrier (BBB) limits the uptake of central nervous system (CNS)-targeting drugs into the brain. Engineering molecular shuttles for active transportation across the barrier has thus potential for improving the efficacy of such drugs. In vitro assessment of potential transcytosis capability for engineered shuttle proteins facilitates ranking and the selection of promising candidates during development. Herein, the development of an assay based on brain endothelial cells cultured on permeable recombinant silk nanomembranes for screening of transcytosis capability of biomolecules is described. The silk nanomembranes supported growth of brain endothelial cells to form confluent monolayers with relevant cell morphology, and induced expression of tight-junction proteins. Evaluation of the assay using an established BBB shuttle antibody showed transcytosis over the membranes with an apparent permeability that significantly differed from the isotype control antibody.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0006291X23006794; http://dx.doi.org/10.1016/j.bbrc.2023.05.093; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85160288308&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/37267863; https://linkinghub.elsevier.com/retrieve/pii/S0006291X23006794; https://dx.doi.org/10.1016/j.bbrc.2023.05.093
Elsevier BV
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