Endogenous retrovirus ERV-DC8 highly integrated in domestic cat populations is a replication-competent provirus
Biochemical and Biophysical Research Communications, ISSN: 0006-291X, Vol: 738, Page: 150521
2024
- 12Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Captures12
- Readers12
- 12
Article Description
Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections in vertebrate genomes and are inherited by offspring. ERVs can produce pathogenic viruses through gene mutations or recombination. ERVs in domestic cats (ERV-DCs) generate feline leukemia virus subgroup D (FeLV-D) through viral recombination. Herein, we characterized the locus ERV-DC8, on chromosome B1, as an infectious replication-competent provirus. ERV-DC8 infected several cell lines, including human cells. Transmission electron microscopy of ERV-DC8 identified the viral release as a Gammaretrovirus. ERV-DC8 was identified as the FeLV-D viral interference group, with feline copper transporter 1 as its viral receptor. Insertional polymorphism analysis showed high ERV-DC8 integration in domestic cats. This study highlights the role, pathogenicity, and evolutionary relationships between ERVs and their hosts.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0006291X2401057X; http://dx.doi.org/10.1016/j.bbrc.2024.150521; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85201280144&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/39153451; https://linkinghub.elsevier.com/retrieve/pii/S0006291X2401057X; https://dx.doi.org/10.1016/j.bbrc.2024.150521
Elsevier BV
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