The role of LncRNA MALAT-1 and MiRNA-9 in Psoriasis
Biochemistry and Biophysics Reports, ISSN: 2405-5808, Vol: 26, Page: 101030
2021
- 18Citations
- 19Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations18
- Citation Indexes18
- 18
- CrossRef6
- Captures19
- Readers19
- 19
Article Description
Psoriasis is a chronic skin disorder manifested by recurrent episodes of scaly, red, itchy skin patches that occur within apparently normal skin. This study was performed to detect the expression of serum and tissue (lesion and non-lesion) LncRNA MALAT-1 and MiRNA-9 that might be used as biomarkers for psoriasis. Blood samples were obtained from 60 psoriasis patients and 40 controls, as well as 4 mm punch biopsy from lesional and non lesional skin of psoriatic patient and normal skin of healthy controls. Expression of LncRNA MALAT-1 and miRNNA-9 in serum and tissues was detected by real time qRT-PCR. a statistically significant increase in the expression of MALAT-1 in lesional and non-lesional skin and serum of psoriatic patients in comparison to controls were detected. Moreover, there was statistically significant increase in serum MiRNA-9 in patients in comparison to controls, while its tissue level was significantly lower in patients. This study highlights the dysregulation of LncRNA MALAT-1 and miRNA-9 in psoriasis. Elevated expression of MALAT-1 in lesional skin of psoriatic patients compared to non-lesional skin may possibly contribute to the development of psoriatic plaques.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S2405580821001242; http://dx.doi.org/10.1016/j.bbrep.2021.101030; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85106486387&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/34095555; https://linkinghub.elsevier.com/retrieve/pii/S2405580821001242; https://dx.doi.org/10.1016/j.bbrep.2021.101030
Elsevier BV
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