Autoclave treatment fails to completely inactivate DLB alpha-synuclein seeding activity
Biochemistry and Biophysics Reports, ISSN: 2405-5808, Vol: 34, Page: 101446
2023
- 4Citations
- 7Captures
- 2Mentions
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Metrics Details
- Citations4
- Citation Indexes4
- Captures7
- Readers7
- Mentions2
- News Mentions2
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Most Recent News
Korea Brain Research Institute Researchers Describe Recent Advances in Nerve Tissue Proteins (Autoclave treatment fails to completely inactivate DLB alpha-synuclein seeding activity)
2023 JUL 06 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Life Science Daily -- Researchers detail new data in nerve tissue proteins.
Article Description
Synucleinopathies are characterized by the deposition of alpha-synuclein (α-syn) aggregates in brain tissue. Pathological α-syn aggregates propagate in a prion-like manner and display prion-like biochemical properties. Using RT-QuIC, we measured α-syn seeding activity from brains of Dementia with Lewy body (DLB) patients post autoclave. Here, we show that autoclaving at 121 °C removes one to two log 10 of α-syn seeding activity but the remaining 50% seeding dose (SD 50 ) is more than 10 7 /mg tissue. DLB brain samples autoclaved at 132 °C still revealed an SD 50 of approximately 10 6 /mg tissue. Our data suggest that DLB α-syn seeds are incompletely inactivated by standard autoclave, thus highlighting the need for evaluating laboratory procedures that fully inactivate them.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S2405580823000274; http://dx.doi.org/10.1016/j.bbrep.2023.101446; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85149284777&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/36923008; https://linkinghub.elsevier.com/retrieve/pii/S2405580823000274; https://dx.doi.org/10.1016/j.bbrep.2023.101446
Elsevier BV
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