Effects of ethanol on cytokine generation and NFκB activity in human lung epithelial cell
Biochemical Pharmacology, ISSN: 0006-2952, Vol: 70, Issue: 4, Page: 545-551
2005
- 7Citations
- 11Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations7
- Citation Indexes7
- CrossRef5
- Captures11
- Readers11
- 11
Article Description
Alcohol abuse is associated with enhanced risk for pulmonary infections, but the mechanisms remain obscure. We assessed whether ethanol reduced generation of cytokines from a human lung epithelial cell line (A549) in vitro and if effects on the NFκB transcription factor were involved. Exposure of A549 to ethanol (0.1–1%) dose-dependently inhibited (by 15–49%) the release of G-CSF and IL-8, but not of M-CSF, triggered by IL1β or TNFα. Ethanol also inhibited by 49% the IL-1β stimulated translocation of the p65 subunit of NFκB from the cytoplasm into the nucleus. Using a κB binding and luciferase coupled construct, transfected into A549 cells, we found that 1% ethanol specifically reduced IL-1β and TNFα induced luciferase activity with 34 and 40%, respectively. Thus, in vitro exposure of lung epithelial cells to ethanol reduced the generation of cytokines, as well as translocation and gene activation by NFκB.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0006295205003266; http://dx.doi.org/10.1016/j.bcp.2005.05.016; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=22144449655&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/15993849; https://linkinghub.elsevier.com/retrieve/pii/S0006295205003266; https://dx.doi.org/10.1016/j.bcp.2005.05.016
Elsevier BV
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