Nucleoside-based anticancer drugs: Mechanism of action and drug resistance
Biochemical Pharmacology, ISSN: 0006-2952, Vol: 215, Page: 115741
2023
- 5Citations
- 46Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations5
- Citation Indexes5
- CrossRef1
- Captures46
- Readers46
- 46
Review Description
Nucleoside-based drugs, recognized as purine or pyrimidine analogs, have been potent therapeutic agents since their introduction in 1950, deployed widely in the treatment of diverse diseases such as cancers, myelodysplastic syndromes, multiple sclerosis, and viral infections. These antimetabolites establish complex interactions with cellular molecular constituents, primarily via activation of phosphorylation cascades leading to consequential interactions with nucleic acids. However, the therapeutic efficacy of these agents is frequently compromised by the development of drug resistance, a continually emerging challenge in their clinical application. This comprehensive review explores the mechanisms of resistance to nucleoside-based drugs, encompassing a wide spectrum of phenomena from alterations in membrane transporters and activating kinases to changes in drug elimination strategies and DNA damage repair mechanisms. The critical analysis in this review underlines complex interactions of drug and cell and also guides towards novel therapeutic strategies to counteract resistance. The development of targeted therapies, novel nucleoside analogs, and synergistic drug combinations are promising approaches to restore tumor sensitivity and improve patient outcomes.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0006295223003325; http://dx.doi.org/10.1016/j.bcp.2023.115741; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85168572435&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/37567317; https://linkinghub.elsevier.com/retrieve/pii/S0006295223003325; https://dx.doi.org/10.1016/j.bcp.2023.115741
Elsevier BV
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