Cyclic hydrostatic pressure and particles increase synthesis of 1,25-dihydroxyvitamin D 3 by human macrophages in vitro
The International Journal of Biochemistry & Cell Biology, ISSN: 1357-2725, Vol: 38, Issue: 9, Page: 1540-1546
2006
- 6Citations
- 6Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations6
- Citation Indexes6
- CrossRef5
- Captures6
- Readers6
Article Description
1,25-Dihydroxyvitamin D 3 has a pivotal role in bone resorption and osteoclast activity. As activated macrophages are known to synthesise 1,25-dihydroxyvitamin D 3, this study examined whether pressure modulated its synthesis. Pressure and particles have been shown to increase synthesis of pro-resorptive cytokines and other factors by cultured macrophages. Human peripheral blood macrophages were isolated, cultured and exposed to pressure (similar to that found in the human joint) and/or particles. Synthesis of 1,25-dihydroxyvitamin D 3 by macrophages was assayed using high pressure liquid chromatography and in situ hybridization. Synthesis of 1,25-dihydroxyvitamin D 3 but not 24,25-dihydroxyvitamin D 3 was increased in macrophages under pressure. In situ hybridization demonstrated an increase in 1α-hydroxylase expression in response to pressure or particles and simultaneous exposure to both stimuli generated higher expression of 1α-hydroxylase. In conclusion, this is the first study to demonstrate that mechanical loading, in the form of pressure, stimulates 1,25-dihydroxyvitamin D 3 synthesis in human macrophages. These findings have implications for the in vivo situation, as they suggest that 1,25-dihydroxyvitamin D 3 could be one factor stimulating osteoclastic bone resorption in pathologies, such as arthritis or implant loosening, where intra-articular or intra-osseous pressure is raised or where wear particles interact with macrophages.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S135727250600094X; http://dx.doi.org/10.1016/j.biocel.2006.03.004; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33747381249&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/16690344; https://linkinghub.elsevier.com/retrieve/pii/S135727250600094X; https://dx.doi.org/10.1016/j.biocel.2006.03.004
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know