LewisX: A neural stem cell specific glycan?
The International Journal of Biochemistry & Cell Biology, ISSN: 1357-2725, Vol: 44, Issue: 6, Page: 830-833
2012
- 29Citations
- 39Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations29
- Citation Indexes29
- 29
- CrossRef26
- Captures39
- Readers39
- 39
Article Description
LewisX (LeX) detecting antibodies are routinely used for cell sorting of neural stem- and progenitor cells (NSPCs). Applications include the enrichment of NSPCs after neural differentiation of human induced pluripotent- or embryonic stem cells, as well as their direct isolation from mouse neural tissue. Nevertheless, only little is known about the role of LeX in the central nervous system. Here we review the current knowledge on LeX-containing glycans expressed by neural stem cells and their progeny. New LeX-carrier proteins and ligands have recently been identified which reveal further insights into the potential function(s) of LeX-glycans. Moreover, evidence accumulates that individual LeX detecting antibody clones vary in their suitability as neural stem cell specific biomarker. Each antibody clone detects a unique LeX-containing glycan epitope. This allows a versatile utilization of anti-LeX antibodies that goes beyond neural stem cell sorting applications.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1357272512000751; http://dx.doi.org/10.1016/j.biocel.2012.02.019; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84860293359&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/22433989; https://linkinghub.elsevier.com/retrieve/pii/S1357272512000751; https://dx.doi.org/10.1016/j.biocel.2012.02.019
Elsevier BV
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