Controllable mineral coatings on PCL scaffolds as carriers for growth factor release
Biomaterials, ISSN: 0142-9612, Vol: 33, Issue: 2, Page: 713-721
2012
- 96Citations
- 96Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations96
- Citation Indexes96
- 96
- CrossRef78
- Captures96
- Readers96
- 96
Article Description
In this study, we have developed mineral coatings on polycaprolactone scaffolds to serve as templates for growth factor binding and release. Mineral coatings were formed using a biomimetic approach that consisted in the incubation of scaffolds in modified simulated body fluids (mSBF). To modulate the properties of the mineral coating, which we hypothesized would dictate growth factor release, we used carbonate (HCO 3 ) concentration in mSBF of 4.2 m m, 25 m m, and 100 m m. Analysis of the mineral coatings formed using scanning electron microscopy indicated growth of a continuous layer of mineral with different morphologies. X-ray diffraction analysis showed peaks associated with hydroxyapatite, the major inorganic constituent of human bone tissue in coatings formed in all HCO 3 concentrations. Mineral coatings with increased HCO 3 substitution showed more rapid dissolution kinetics in an environment deficient in calcium and phosphate but showed re-precipitation in an environment with the aforementioned ions. The mineral coating provided an effective mechanism for growth factor binding and release. Peptide versions of vascular endothelial growth factor (VEGF) and bone morphogenetic protein 2 (BMP2) were bound with efficiencies up to 90% to mineral mineral-coated PCL scaffolds. We also demonstrated sustained release of all growth factors with release kinetics that were strongly dependent in the solubility of the mineral coating.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0142961211011872; http://dx.doi.org/10.1016/j.biomaterials.2011.09.095; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=80055111639&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/22014948; https://linkinghub.elsevier.com/retrieve/pii/S0142961211011872; https://dx.doi.org/10.1016/j.biomaterials.2011.09.095
Elsevier BV
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