Synthesis, in vitro evaluation and molecular docking studies of biscoumarin thiourea as a new inhibitor of α-glucosidases
Bioorganic Chemistry, ISSN: 0045-2068, Vol: 63, Page: 36-44
2015
- 53Citations
- 27Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations53
- Citation Indexes53
- 53
- CrossRef29
- Captures27
- Readers27
- 27
Article Description
Biscoumarin analogs 1–18 have been synthesized, characterized by EI-MS and 1 H NMR and evaluated for α-glucosidase inhibitory potential. All compounds showed variety of α-glucosidase inhibitory potential ranging in between 13.5 ± 0.39 and 104.62 ± 0.3 μM when compared with standard acarbose having IC 50 value 774.5 ± 1.94 μM. The binding interactions of the most active analogs were confirmed through molecular docking. The compounds showed very good interactions with enzyme. All synthesized compounds 1–18 are new. Our synthesized compounds can further be studied to developed lead compounds.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0045206815300195; http://dx.doi.org/10.1016/j.bioorg.2015.09.004; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84942945274&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/26432614; https://linkinghub.elsevier.com/retrieve/pii/S0045206815300195; https://dx.doi.org/10.1016/j.bioorg.2015.09.004
Elsevier BV
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