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A phytotherapic blend immunity-6™ inhibits myeloid leukemic cells 2 activation involving purinergic signaling

Biomedicine & Pharmacotherapy, ISSN: 0753-3322, Vol: 159, Page: 114263
2023
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Research Conducted at Federal University of Sao Paulo (UNIFESP) Has Updated Our Knowledge about Leukemia (A Phytotherapic Blend Immunity-6tm Inhibits Myeloid Leukemic Cells 2 Activation Involving Purinergic Signaling)

2023 MAR 10 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Hematology Daily -- Investigators publish new report on Oncology - Leukemia. According

Article Description

Leukemia is among the most common types of hematological cancers and the use of herbal medicines to prevent and treat leukemia are under quick development. Among several molecular pathways involved in leukemia pathogenesis and exacerbations, purinergic signaling is revealed as a key component. In the present study, the effects of two doses (5 ug/mL and 10 ug/mL) of Immunity-6™, a phytocomplex composed by beta-glucan, green tea (Camelia sinensis), chamomile (Matricaria chamomilla), and ascorbic acid (vitamin C) was tested in vitro, using chronic myelogenous leukemia cell line (K-562; 5 ×104/mL/well), which were challenged with lipopolysaccharide (LPS; 1 ug/mL) for 24 h. The results demonstrated that both doses of Immunity-6™ inhibited ATP release (p < 0.001) and P2×7 receptor at mRNA levels expression (p < 0.001). Purinergic inhibition by Immunity-6™ was followed by reduced release of proinflammatory cytokines IL-1beta (p < 0.001) and IL-6 (p < 0.001), while only 5 ug/mL of Immunity-6™ reduced the release of TNF-alpha (p < 0.001). Beyond to inhibit the release of pro-inflammatory cytokines, both doses of Immunity-6™ induced the release of anti-inflammatory cytokine IL-10 (p < 0.001), while only the higher dose (10 ug/mL) of Immunity-6™ induced the release of anti-inflammatory IL-1ra (p < 0.05) and klotho (p < 0.001). Thus, Immunity-6™ may be a promising adjuvant in the treatment of leukemia and further clinical trials are guaranteed.

Bibliographic Details

Bella, Yanesko Fernandes; Oliveira, Carlos Rocha; Mateus-Silva, José Roberto; Brandao-Rangel, Maysa Alves Rodrigues; Silva-Reis, Anamei; Santos, Juliana de Melo Batista; Albertini, Regiane; Lopes-Martins, Rodrigo Alvaro Brandao; de Oliveira, Luis Vicente Franco; Vieira, Rodolfo P

Elsevier BV

Pharmacology, Toxicology and Pharmaceutics

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