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Pinostrobin alleviates testicular and spermatological damage induced by polystyrene microplastics in adult albino rats

Biomedicine & Pharmacotherapy, ISSN: 0753-3322, Vol: 162, Page: 114686
2023
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University of Agriculture Reports Findings in Hormones (Pinostrobin alleviates testicular and spermatological damage induced by polystyrene microplastics in adult albino rats)

2023 APR 21 (NewsRx) -- By a News Reporter-Staff News Editor at Middle East Daily -- New research on Hormones is the subject of a

Article Description

Polystyrene microplastics (PS-MPs) have become major environmental pollutants that adversely effects multiple organs specifically testicles. Pinostrobin (PN) is an important flavonoid which, shows several pharmacological potentials. The current study was designed to elucidate the mitigative effects of PN against PS-MPs induced testicular toxicities in rats. 48 male albino rats were randomly distributed into 4 groups, control, PS-MPs group (0.01 mg/kg), PS-MPs + PN group (0.01 mg/kg of PS-MPs; 40 mg/kg of PN) and PN group (40 mg/kg). PS-MPs intoxication substantially lessened the activities of glutathione peroxidase (GPx), glutathione reductase (GSR), superoxide dismutase (SOD) along with catalase (CAT) while, raised the level of malondialdehyde (MDA) as well as reactive oxygen species (ROS). Additionally, PS-MPs reduced luteinizing hormone (LH), plasma testosterone, follicle-stimulating hormone (FSH) concentration, sperm motility, sperm count, expression of steroidogenic enzymes and Bcl-2 (anti-apoptotic protein) along with the count of spermatogenic cells. While, dead sperm count, sperm abnormalities (tail, neck and head), Bax and caspase-3 (apoptotic proteins) expression along with histopathological anomalies were elevated. Moreover, PS-MPs exposure increased the level of inflammatory markers. However, PN treatment considerably decreased oxidative stress (OS) by reducing ROS as well as increased sperm motility and alleviated all the damages induced by the PS-MPs. Therefore, it is concluded that PN may prove a potential therapeutic candidate to restore all the PS-MPs-induced testicular toxicities.

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